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circos plot of p-value of association between CAD and variation in the Genome across multiple ancestry groups. Picture similar to our the figure 1 of our paper: Large-scale genome-wide association study of coronary artery disease in genetically diverse populations, Nat Medicine, 2022, PMCID: PMC9419655

Genome wide association study of Coronary Artery Diseases

Tcheandjieu lab is interested in understanding the genetic architecture of complex diseases to develop approaches for risk prediction and therapeutic targeting. We have a particular interest in studying ancestry groups that have historically been under-studied such as African, Hispanic, Native American and indigenious populations around the world. Some of the projects in the lab include:

  • Characterizing the relationship between candidate variants and diseases across ancestries and propose candidate causal variants for prioritization.

  • Developing  polygenic risk scores that accurately predict the risk of diseases in all ancestry groups, particularly African ancestry groups in which currently developed PRS have consistently failed.

  • Characterizing the pleiotropy of candidate causal variants


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